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LAL-D (lysosomal acid lipase deficiency) is a rare and progressive disease where cholesterol processing in the body is disrupted causing fat accumulation in different body systems.

LAL-D affects people of all ages, from infancy to adulthood. In infants, LAL-D is a medical emergency, worsens quickly, and requires immediate medical care. In children and adults, it is progressive and may lead to serious complications which can occur anytime without warning.


Infants with LAL-D typically survive for only 6-12 months if left untreated

50% of patients experience a number of symptons

In a study of 48 pediatric and adult patients with LAL-D nearly 50% of patients experienced thickening or scarring of liver tissue (hepatic fibrosis), chronic scarring of the liver (cirrhosis), or underwent liver transplant within 3 years of first clinical appearance

Get to Know LAL-D

Understand the common signs and symptoms of LAL-D

What is LAL-D?

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Signs of LAL-D

Common signs and symptoms

What you need to know about LAL-D

Your family & LAL-D

What you need to know

Get tested for LAL-D

Get Tested for LAL-D with a simple blood test

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If you or your loved ones have received a diagnosis of LAL-D, you can help your family by making sure other family members get tested too. Since LAL-D is usually passed from parents to children, other family members may be affected too. Get involved in the rare disease community, and get help and support for yourself and your family.