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What is LAL-D?
(Lysosomal acid lipase deficiency)

Historically known as Wolman Disease in infants and cholesteryl ester storage disease (CESD) in children and adults, LAL-D is caused by mutations in the LIPA gene, leading to the deficiency of LAL enzyme.

How does LAL-D occur?

How does LAL-D Occur?

LAL-D occurs when a person inherits a defective copy of the LIPA gene from both parents. In these situations LAL enzyme either does not work properly or is not made at all.

Health Risks Associated with LAL-D

Health Risks Associated with LAL-D

LAL-D may affect many vital organs such as the liver, spleen, heart, and the digestive tract, and can cause complications in organ systems.

LAL-D diagnosis is commonly delayed

Why LAL-D Diagnosis is commonly delayed

Patients with LAL-D are often misdiagnosed because LAL-D shares symptoms with other conditions such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), familial combined hyperlipidemia (FCH), heterozygous familial hypercholestrolemia (HeFH), metabolic syndrome, and cardiovascular disease.

Early Diagnosis is Key

Early management may reduce the risk of serious complications – talk to your/your loved one’s doctor about symptoms you/they are experiencing and if testing for LAL-D is right for you/them.

LAL-D is inherited disease

LAL-D is an Inherited DISEASE

LAL-D Impact health

LAL-D Impacts Health

LAL-D diagnosis is frequently delayed

LAL-D diagnosis is frequently delayed

Talk to your doctor

Talk to YOUR/YOUR LOVED ONE’S doctor about signs and symptoms of LAL-D and testing

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